Production of luteoskyrin, a hepatotoxic pigment, by Penicillium islandicum Sopp.
نویسندگان
چکیده
Various factors affecting the yields of luteoskyrin, a hepatotoxic mycotoxin, and related pigments in the liquid medium were studied. Maximal yields of luteoskyrin (0.13% by isolation) and of other pigments were attained in the late phase of the cultivation. The yield of the pigment was increased by supplying malt extract, malonic acid, glutamic acid, or asparagine. A useful material for preparation of (14)C-labeled luteoskyrin was 2-(14)C-malonate.
منابع مشابه
Production of luteoskyrin and isolation of a new metabolite, pibasterol, from Penicillium islandicum Sopp.
Production of luteoskyrin, a hepatotoxin synthesized by Penicillium islandicum Sopp., was studied with various fermentation methods. Best results were obtained in static fermentations on glutinous rice at 30 degrees C. The isolated yield of pure luteoskyrin was approximately 400 mg per kg of rice. Also produced were skyrin, islandicin, iridoskyrin, rubroskyrin, chrysophanol, mannitol, and eryth...
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ورودعنوان ژورنال:
- Applied microbiology
دوره 18 3 شماره
صفحات -
تاریخ انتشار 1969